I hit my early 40s last year. Not old, but not young either.

That’s when the afternoon crashes started hitting different. You know the feeling – 2 PM rolls around and suddenly your eyelids weigh 50 pounds. Coffee helps for an hour, then you crash harder. Recovery from workouts? Forget about it. What used to take a day now takes three.

Enter Renue By Science and their Total NAD Restoration Protocol. I’d been reading about NAD+ decline (apparently we lose half our levels by middle age – terrifying) and this kit promised something different. Not just another NAD booster, but a whole system targeting multiple aging pathways.

Eight weeks later, here I am. Did it work? Let’s dig in.

What is the Total NAD Restoration Protocol?

Four supplements. One goal: cellular rejuvenation.

The Total NAD Restoration Protocol includes NAD+ Complete, Senolytique, Energizer AM, and Restore PM. Think of it as a coordinated assault on aging – while one supplement boosts NAD+, another clears out zombie cells, a third supercharges your mitochondria, and the fourth ensures deep, restorative sleep.

But why NAD+? Simple: it’s the molecule that keeps your cells humming. Powers hundreds of enzymatic reactions. Repairs DNA. Without it, cells literally can’t produce energy efficiently. The kicker? NAD+ levels nosedive as we age – we’re talking 40-50% decline by our 40s and 50s. No wonder we feel like crap.

Quick note: If you’re ready to jump in, grab the Total NAD Restoration Protocol here and use code BRAINFLOW to save 10% on your order. That’s what I did, and it knocked a nice chunk off the price.

My Starting Point (Spoiler: Not Great)

Here’s where I was: early 40s, decent shape on paper, falling apart in practice. Energy levels reminiscent of a sloth. Brain fog thick enough to cut with a knife. Sleep? Sure, I got 7-8 hours, but I’d wake up feeling like I’d been hit by a truck.

I’d tried standalone NMN before (check out my detailed review of Renue’s NMN here). Meh results. But this comprehensive approach intrigued me. Could hitting multiple aging mechanisms simultaneously actually move the needle?

Time to find out.

Breaking Down Each Component

NAD+ Complete: The Morning Game-Changer

Two capsules. Empty stomach. Every morning.

This bad boy packs NMN, NR, and Trigonelline in a liposomal formula. Translation: it’s like a triple-threat of NAD+ precursors wrapped in a delivery system that actually gets absorbed (Renue claims >90% bioavailability vs the usual 10% – huge if true).

The science backs it up. Clinical trials on NMN show significant NAD+ increases in middle-aged adults. Real studies, real humans, real results.

Week 2 hit different. That 2 PM wall? Still there, but more like a speed bump. By week 4, I added an extra mile to my runs without dying. Placebo? Maybe. But when you’re cruising through afternoons without mainlining espresso, who cares?

Senolytique: The Zombie Cell Assassin

Twice weekly. No more, no less.

Senolytique contains Quercetin, Fisetin, and Spermidine – sounds like a Harry Potter spell, works like cellular spring cleaning. These compounds hunt down senescent cells (the zombies that accumulate with age and spew inflammatory garbage).

The Mayo Clinic dropped a bombshell study showing fisetin extended lifespan in mice by 10%. Not just healthspan – actual lifespan. And spermidine? It triggers autophagy – basically Marie Kondo-ing your cells.

You can’t feel cells dying. But around week 4, something shifted. Morning stiffness? Gone. Post-workout soreness? Cut in half. Even my seasonal allergies chilled out (senescent cells pump out inflammatory signals – maybe there’s a connection?).

Weird but true: I started waking up actually refreshed. Not “okay I guess I’m awake now” but genuinely ready to tackle the day.

Energizer AM: Liquid Motivation

Remember being 25 and bouncing out of bed? This is the closest I’ve gotten since.

Energizer AM with Resveratrol, EGCG, and Hesperidin might sound like a wellness influencer’s smoothie recipe, but the research is legit. Resveratrol activates SIRT1, mimicking calorie restriction benefits. (Fun fact: resveratrol is one of Dr. David Sinclair’s core longevity supplements). Hesperidin improved cycling performance in athletes after 8 weeks.

Combined with NAD+ Complete, mornings became my superpower. Clean energy, no jitters, no crash. Week 6, I destroyed my personal best on a 10-mile bike ride. On a Tuesday. The steady, sustained energy felt different from coffee – less “LET’S GO!” and more “I could do this all day.”

Best part? No 3 PM face-plant into my keyboard.

Restore PM: The Sleep Alchemist

GABA, 5-HTP, Apigenin, Melatonin, and Glutathione walk into a bar… and put everyone to sleep.

Bad joke, but this nighttime formula is no laughing matter. Studies show GABA/5-HTP combos significantly improve sleep quality. Apigenin binds to GABA receptors, creating a natural sedative effect.

My sleep tracking app told the story: average time to fall asleep dropped from 45 to 20 minutes. Middle-of-the-night wake-ups? Nearly eliminated. But numbers don’t capture the feeling of waking up actually restored, not just conscious.

Pro tip: Take it on a full stomach. I learned this the hard way via 5-HTP-induced heartburn. Lesson learned.

Eight Weeks Later: The Verdict

The Good Stuff

Energy? Through the roof. Not manic, bouncing-off-walls energy, but sustained, clean fuel that lasted all day. Friends started asking if I’d had work done. (Is cellular rejuvenation considered work?)

Sleep quality transformed everything else. Better mood, clearer skin, sharper thinking. My resting heart rate dropped 5 BPM. VO2 max increased from 42 to 44. Small changes, but trending in the right direction.

Recovery time cut in half. Sunday’s long run no longer meant Tuesday’s hobble. Joints stopped creaking like a haunted house. Even my skin looked… alive? Hydrated? Whatever it was, I’ll take it.

The Not-So-Good

Let’s be real: $207 for a month’s supply isn’t pocket change. That’s a car payment for some people. The pill schedule takes commitment – mornings require NAD+ Complete and Energizer AM, evenings need Restore PM, and don’t forget Senolytique twice weekly. Miss a few doses and you’ll notice.

The NAD+ Complete went on backorder during my second month. Popular product problems, but annoying when you’re in a groove. Plan ahead.

Also, this specific combination hasn’t been studied as a complete protocol. We’re connecting dots from individual ingredient studies. Your mileage may vary.

Sensitive stomachs beware – the liposomal formulas are rich. Start slow, take with food when needed.

How It Stacks Up

I’ve tried standalone NMN. I’ve tried resveratrol. I’ve tried them all separately. This hits different.

It’s the synergy. While basic NAD+ boosters give you energy, they don’t clear senescent cells. They don’t optimize sleep. They don’t turbocharge mitochondria. Trying to recreate this stack yourself? Good luck matching the quality and bioavailability of Renue’s liposomal delivery system.

The Reddit community even has threads on optimal timing – that’s how dedicated the user base is.

Bottom Line: Worth Every Penny

Eight weeks changed my perspective on aging. This isn’t about turning back the clock – it’s about making sure the clock keeps accurate time.

The Total NAD Restoration Protocol delivered. More energy, better sleep, faster recovery, mental clarity – check, check, check, and check. It’s comprehensive, science-backed, and actually works.

Is it perfect? No. Is it cheap? Definitely not. But if you’re serious about longevity and tired of half-measures, this is the real deal. Renue By Science created something special here – a coordinated attack on aging that actually moves the needle.

I’m continuing the protocol. The benefits far outweigh the cost and minor inconveniences. In my early 40s, I feel better than I did a decade ago. That’s not marketing fluff – that’s my lived experience.

Will it work for you? Only one way to find out. But if you’re reading this, exhausted at 2 PM, wondering where your energy went – maybe it’s time to restore what time took away.

Your cells will thank you.

Remember: Use code BRAINFLOW at checkout to save 10% on your Total NAD Restoration Protocol order.